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Writer's pictureIryna Verbas

Topical Estrogen: A New Approach to Combating Age-Related Skin Changes


спокойная и уверенная женщина

In recent years, hormone therapy has garnered increasing attention in the context of women’s health. One particularly interesting discovery is the use of topical estrogen to improve the skin’s condition during perimenopause and menopause. This topic has sparked growing interest among both specialists and patients, as estrogen has a significant impact on the skin, especially as it ages.


Estrogen and Its Role in the Body

Estrogen is a hormone primarily responsible for a woman’s reproductive health. It is produced by the ovaries but is also made in smaller amounts by fat cells and the adrenal glands. However, estrogen’s role in the body extends far beyond reproductive function. It plays a part in regulating cardiovascular health, maintaining bone density, and even influencing cognitive functions.

As women age, estrogen levels begin to decline, especially during perimenopause—the period preceding menopause—when many women notice changes in their bodies, including a deterioration in skin quality. This period is marked by fluctuating hormone levels, which can cause unpleasant symptoms such as hot flashes, irritability, fatigue, and, of course, age-related skin changes.


How Estrogen Decline Affects the Skin

The skin is one of the organs heavily influenced by estrogen. During perimenopause and menopause, many women notice their skin becoming drier, more sensitive, and less elastic. This is because estrogen plays a key role in maintaining skin hydration, stimulating collagen production, and supporting blood circulation.

The decrease in estrogen levels leads to a rapid loss of collagen—the protein responsible for the skin’s density and elasticity. Research shows that women can lose up to 30% of their collagen within the first five years after menopause. This explains why the skin starts to feel "looser," drier, and less firm. Additionally, the production of hyaluronic acid decreases, further reducing the skin’s ability to retain moisture.


How Does Topical Estrogen Work?

The use of topical estrogen is aimed at locally replenishing hormone levels in the skin, which may help slow down or partially reverse the signs of aging. While systemic hormone therapy also positively affects the skin, it comes with its own limitations and risks, such as an increased risk of breast cancer and other conditions. Topical estrogen, however, works locally, minimizing systemic effects and potential side effects.

Although the studies are still relatively small, scientific research confirms that topical estrogen can increase collagen synthesis, improve skin hydration, and boost elasticity. Many women who have used this method report significant improvements in skin condition, especially in areas like the face, neck, and hands.


How and Where to Apply Topical Estrogen

Topical estrogen is most commonly prescribed for vaginal use to combat menopause symptoms such as dryness, discomfort, and tissue atrophy. However, many dermatologists and gynecologists also recommend its use to improve skin quality on the face and other parts of the body.

Applying estrogen creams to the face, neck, and hands may contribute to rejuvenating the skin. However, it is essential to remember that this process should be monitored by a doctor. Estrogen creams may cause irritation, redness, or the appearance of spider veins. Some women may also experience a worsening of conditions like melasma, a hormone-related pigmentation disorder.


Safety and Side Effects

One of the most pressing questions surrounding the use of topical estrogen is its safety. While studies suggest that systemic absorption of the hormone through the skin is minimal, data on long-term risks are still limited. It’s important to consider each woman’s medical history, especially if she has previously been diagnosed with breast cancer or other hormone-dependent conditions. Nevertheless, many experts agree that using topical estrogen in small doses and on limited areas of the skin may be safe even for women with a higher risk.

According to research, local estrogen application to mucous membranes, such as in the vagina, does not increase the risk of breast or uterine cancer. Therefore, it can be assumed that applying it to the face or hands will not cause significant systemic effects if used in limited amounts.


Conclusion

Topical estrogen represents an interesting and promising direction in skincare during menopause. It may help restore some of the skin’s youthful appearance and elasticity. However, its use requires a careful approach and consultation with a doctor. It is important to consider potential risks and undergo regular medical check-ups.

Questions about the use of topical estrogen remain relevant, and further research will help to more accurately determine its efficacy and safety. If anyone has already used or prescribed it for skincare, we look forward to your comments and feedback!

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